Development of a multi-modal tactile force sensing system for deep-sea applications

With the increasing demand for autonomy in robotic systems, there is a rising need for sensory data sensed via different modalities. In this way system states and the aspects of unstructured environments can be assessed in the most detailed fashion possible, thus providing a basis for making decisions regarding the robotâ s task. Com- pared to other sensing modalities, the sense of touch is underrepresented in todayâ s robots. That is where this thesis comes in. A tactile sensing system is developed that combines several modalities of contact sensing. The use of the tactile sense in robotic grippers is of great relevance especially for robotic systems in the deep sea. Up to now manipulation systems in master-slave control mode have been used in this area of application. An operator performing the manipulation task has to rely on visual feedback coming from cameras. Working on the oceanâ s seafloor means having to cope with conditions of limited visibility caused by swirled-up sediment

Literatur-Rundschau

Literatur-RundschauReinhold Zwick, Evangelienrezeption im Jesusfilm. Ein Beitrag zur intermedialen Wirkungsgeschichte des Neuen Testaments (Peter Hasenberg)John R. May (Editor), New Image of Religions Film (Communication, Culture and Theology) (Wolfgang Luley)Georg Langenhorst, Jesus ging nach Hollywood. Die Wiederentdeckung J esu in Literatur und Film der Gegenwart (Susanne Kampmann)Michael Jäckel/Peter Winterhoff-Spurk (Hg.), Mediale Klassengesellschaft? Politische und soziale Folgen der Medienentwicklung (Susanne Kampmann

UTCI-Fiala multi-node model of human heat transfer and temperature regulation.

The UTCI-Fiala mathematical model of human temperature regulation forms the basis of the new Universal Thermal Climate Index (UTC). Following extensive validation tests, adaptations and extensions, such as the inclusion of an adaptive clothing model, the model was used to predict human temperature and regulatory responses for combinations of the prevailing outdoor climate conditions. This paper provides an overview of the underlying algorithms and methods that constitute the multi-node dynamic UTCI-Fiala model of human thermal physiology and comfort. Treated topics include modelling heat and mass transfer within the body, numerical techniques, modelling environmental heat exchanges, thermoregulatory reactions of the central nervous system, and perceptual responses. Other contributions of this special issue describe the validation of the UTCI-Fiala model against measured data and the development of the adaptive clothing model for outdoor climates

Immunization: vital progress, unfinished agenda.

Vaccination against infectious diseases has changed the future of the human species, saving millions of lives every year, both children and adults, and providing major benefits to society as a whole. Here we show, however, that national and sub-national coverage of vaccination varies greatly and major unmet needs persist. Although scientific progress opens exciting perspectives in terms of new vaccines, the pathway from discovery to sustainable implementation can be long and difficult, from the financing, development and licensing to programme implementation and public acceptance. Immunization is one of the best investments in health and should remain a priority for research, industry, public health and society

Meta-analysis identification of highly robust and differential immune-metabolic signatures of systemic host response to acute and latent tuberculosis in children and adults

Background: Whole blood expression profiling is a mainstay for delineating differential diagnostic signatures of infection yet is subject to high variability that reduces power and complicates clinical usefulness. To date, confirmatory high confidence expression profiling signatures for clinical use remain uncertain. Here we have sought to evaluate the reproducibility and confirmatory nature of differential expression signatures, comprising molecular and cellular pathways, across multiple international clinical observational studies investigating children and adult whole blood transcriptome responses to tuberculosis (TB). Methods and findings: A systematic search and quality control assessment of gene expression repositories for human TB using whole blood resulted in 11 datasets with a total of 1073 patients from Africa, Europe, and South America. A non-parametric estimation of percentage of false prediction was used for meta-analysis of high confidence differential expression analysis. Deconvolution analysis was applied to infer changes in immune cell proportions and enrichment tests applied using pathway database resources. Meta-analysis identified high confidence differentially expressed genes, comprising 372 in adult active-TB versus latent-TB (LTBI), 332 in adult active-TB versus controls (CON), five in LTBI versus CON, and 415 in childhood active-TB versus LTBI. Notably, these confirmatory markers have low representation in published signatures for diagnosing TB. Pathway biology analysis of high confidence gene sets revealed dominant metabolic and innate-immune pathway signatures while suppressed signatures were enriched with adaptive signaling pathways and reduced proportions of T and B cells. Childhood TB showed uniquely strong inflammasome antagonist signature (IL1RN and ILR2), while adult TB patients exhibit a significant preponderance type I and type II IFN markers. Key limitations of the study include the paucity of data on potential confounders. Conclusion: Meta-analysis identified high confidence confirmatory immune-metabolic and cellular expression signatures across studies regardless of the population resource setting, HIV status and circulating endemic pathogens. Notably, previously identified diagnostic signature markers for TB show limited concordance with the confirmatory meta-analysis. Overall, our results support the use of the confirmatory expression signatures for guiding optimized diagnostic, prognostic, and therapeutic monitoring modalities in TB

Hyperlipidemia is a risk factor for osteonecrosis in children and young adults with acute lymphoblastic leukemia

TesisLa intoxicación con plomo es un problema de trascendental importancia para la salud pública por sus efectos en la calidad de vida de las personas, particularmente de los niños expuestos. La presente investigación fue de tipo descriptivo transversal y se realizó con la finalidad de determinar los niveles de plomo sanguíneo en los habitantes del Centro Poblado de Taca, durante los meses de junio y julio de 2013. Participaron del estudio 42 personas voluntarias: 32 varones y 10 mujeres, cuya media de edad fue de 33,23 años (rango: 21-72 años). Se tomaron muestras de sangre mediante venopunción previo consentimiento informado, utilizando tubos al vacío con anticoagulante, se mantuvieron bajo refrigeración a 8 °C, se trataron con mezcla sulfonítrica - ácido nítrico concentrado a ebullición lenta en un equipo de digestión y luego leídas en un espectrofotómetro de absorción atómica Thermo Scientific ¡CE 3300 a 217 nm. Se obtuvieron los siguientes resultados: todos los sujetos estudiados presentan algún grado de contaminación con plomo, encontrándose un nivel de plumbemia medio de 26,62 ug/dl y los niveles de plomo en sangre de varones y mujeres de 18 a 72 años de edad, encontrándose medias de 33,96 y 3,16 ug/dl, respectivamente, existiendo relación entre el género y plumbemia (p<0,05). El nivel de plomo en sangre de los habitantes del Centro Poblado de Taca, Distrito Canaria, Provincia de Víctor Fajardo, se incrementa en función del tiempo de residencia, por lo que existe relación entre estas dos variables (P<0,05)

Relationship Between Time Consumption and Quality of Responses to Drug-Related Queries : A Study From Seven Drug Information Centers in Scandinavia

Paid Open Acces

An introduction to the Universal Thermal Climate Index (UTCI)

The assessment of the thermal environment is one ofthe main issues in bioclimatic research, and more than 100 simple bioclimatic indices have thus far been developed to facilitate it. However, most of these indices have proved to be of limited applicability, and do not portroy the actual impacts of thermal conditions on human beings. Indices derived from human heatbalance models (one- or two-node) have been found to offer a better representation of the environmental impact in question than do simple ones. Indeed, the new generation of multi-node models for human heat balance do allow full account to be taken of heat transfer and exchange, both within the human body and between the body surface and the surrounding air layer. In this paper, it is essential background information regarding the newly-developed Universal Thermal Climate Index UTCI that is presented, this in fact deriving from the Fiala multi-node model of human heatbalance. The UTCI is defined as the air temperature (Ta) of the reference condition causing the same model response as actual conditions. UTCI was developed in 2009 by virtue of international co-operation between leading experts in the areas of human thermophysiology, physiological modelling, meteorology and climatology. The necessary research for this had been conducted within the framework of a special commission of the International Society of Biometeorology (ISB) and European COST Action 730

Deriving the operational procedure for the Universal Thermal Climate Index (UTCI)

The Universal Thermal Climate Index (UTCI) aimed for a one-dimensional quantity adequately reflecting the human physiological reaction to the multi-dimensionally defined actual outdoor thermal environment. The human reaction was simulated by the UTCI-Fiala multi-node model of human thermoregulation, which was integrated with an adaptive clothing model. Following the concept of an equivalent temperature, UTCI for a given combination of wind speed, radiation, humidity and air temperature was defined as the air temperature of the reference environment, which according to the model produces an equivalent dynamic physiological response. Operationalising this concept involved (1) the definition of a reference environment with 50% relative humidity (but vapour pressure capped at 20 hPa), with calm air and radiant temperature equalling air temperature and (2) the development of a one-dimensional representation of the multivariate model output at different exposure times. The latter was achieved by principal component analyses showing that the linear combination of 7 parameters of thermophysiological strain (core, mean and facial skin temperatures, sweat production, skin wettedness, skin blood flow, shivering) after 30 and 120 min exposure time accounted for two-thirds of the total variation in the multi-dimensional dynamic physiological response. The operational procedure was completed by a scale categorising UTCI equivalent temperature values in terms of thermal stress, and by providing simplified routines for fast but sufficiently accurate calculation, which included look-up tables of pre-calculated UTCI values for a grid of all relevant combinations of climate parameters and polynomial regression equations predicting UTCI over the same grid. The analyses of the sensitivity of UTCI to humidity, radiation and wind speed showed plausible reactions in the heat as well as in the cold, and indicate that UTCI may in this regard be universally useable in the major areas of research and application in human biometeorology

Measurement of Aerodynamically Induced Blade Distortion on a Shrouded Counter-Rotating Prop-Fan

Blade deformation on a 1 m diameter composite fan rotor is measured simultaneously using stereoscopic image pattern correlation technique (IPCT) and blade-tip imaging. Absolute referencing of the blades is made possible by simultaneously tracking a marker on the hub using a fourth camera. Illumination is provided by microsecond pulses of high-power LEDs. Rise and fall time in the 100ns regime are achieved using a self-designed high-current drive circuit. A high-speed microcontroller provides accurate, speed-independent angular delays to enable phase-locked triggering of cameras and LEDs. Mean and RMS deformation of the blade are acquired for different aerodynamic loading conditions induced by imposing a non-uniformity upstream of the rotor aimed at mimicking boundary layer ingestion